malaise : (n) a general feeling of discomfort, illness, or uneasiness, whose exact cause is difficult to determine
Malaise struck him in August and refused to lift until November; he got nothing done and drove his friends to distraction.
Right now I associate it with the song “Two Weeks” by Grizzly Bear. See the following audio post for more information!
(But seriously, I love this word. Not the concept it expresses—at least, not as it relates to my life—but the word itself. Which doesn’t make any sense, but there you go.)